The decrease of intraflagellar transport impairs sensory perception and metabolism in ageing

Abstract Sensory perception and metabolic homeostasis are known to deteriorate with ageing, impairing the health of aged animals, while mechanisms underlying their deterioration remain poorly understood. The potential interplay between declining sensory impaired metabolism during ageing is also barely explored. Here, we report that intraflagellar transport (IFT) in cilia neurons nematode Caenorhabditis elegans due a daf-19 /RFX-modulated decrease IFT components. We find reduced thus impairs ageing. Moreover, demonstrate whereas IFT-dependent worms has mild impact on insulin/IGF-1 signalling, it remarkably suppresses AMP-activated protein kinase (AMPK) signalling across tissues. show upregulating /RFX effectively enhances IFT, perception, AMPK activity autophagy, promoting longevity. Our study determines an pathway causing decay deterioration, which turn disrupts healthy